5/15/2025
Last update
5/15/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.7
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.6
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Organic Turmeric BlendOrganic Turmeric Root Extract standardized to 95% curcuminoids, Organic Fermented Turmeric Root (blend yielding 500 mg curcuminoids)
630 mg
+
Organic Fermented Ginger Root
50 mg
+
Organic Black Pepper Fruit Extract
7 mg
+
Probiotic BlendBifidobacterium lactis Bl-04Lactobacillus acidophilus La-14
4 mg
+
Top Medical Research Studies
9
In a well-structured study involving 101 adults suffering from knee osteoarthritis, we explored the effects of curcumin, a compound derived from turmeric, on knee pain. Participants were randomly assigned to receive either 500 mg of a standardized curcumin extract, Curcugen, twice daily, or a placebo for eight weeks, allowing for a clear comparison of its effectiveness.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
Read More
9
We sought to determine the effectiveness of Curcuma longa extract, commonly known as turmeric, in alleviating knee pain associated with osteoarthritis. Our investigation focused on randomized controlled trials that compared turmeric extract with placebo, analyzing data from notable databases like PubMed and Cochrane Library through April 2021.
In total, we reviewed 10 trials encompassing 783 patients. The outcomes of our analysis were quite promising. We found that patients taking Curcuma longa experienced significantly greater relief from pain and improved overall function compared to those given a placebo. Notably, the measures used to assess pain and functionality showed results that exceeded the minimum clinically important differences, meaning that the improvements were not just statistically significant but also meaningful in real life.
This evidence suggests that incorporating turmeric extract into treatment plans may offer substantial benefits for those suffering from knee osteoarthritis. However, we must acknowledge that the studies we reviewed exhibited some variability, indicating a need for further high-quality research with larger participant groups to corroborate our findings on turmeric’s effectiveness.
In total, we reviewed 10 trials encompassing 783 patients. The outcomes of our analysis were quite promising. We found that patients taking Curcuma longa experienced significantly greater relief from pain and improved overall function compared to those given a placebo. Notably, the measures used to assess pain and functionality showed results that exceeded the minimum clinically important differences, meaning that the improvements were not just statistically significant but also meaningful in real life.
This evidence suggests that incorporating turmeric extract into treatment plans may offer substantial benefits for those suffering from knee osteoarthritis. However, we must acknowledge that the studies we reviewed exhibited some variability, indicating a need for further high-quality research with larger participant groups to corroborate our findings on turmeric’s effectiveness.
Read More
9.5
We aimed to understand how curcumin, a compound found in turmeric, impacts knee pain in individuals suffering from osteoarthritis (OA). Using various databases, we gathered and analyzed data from multiple meta-analyses that included randomized controlled trials focused on curcumin's effects on OA symptoms up to September 2023.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
Read More
Most Useful Reviews
10
Knee pain relief
2 people found this helpful
I have been taking this product for six months, and my osteoarthritis knee pain has almost disappeared. I keep purchasing it and no longer require anti-inflammatories. I wholeheartedly recommend it.
Read More
9
Avoided surgery
2 people found this helpful
My doctor told me I would need knee surgery, but I opted to try this turmeric first. Two years later, I’m thrilled to say I still haven’t needed surgery!
Read More
9
Reduced discomfort noted
After using the Turmeric Maximum Strength Joints & Mobility Supplement for about six weeks, I noticed a significant reduction in joint discomfort, notably in my knees. Initially, I experienced morning stiffness, but after consistent use, I have greater flexibility and less pain, particularly post-exercise.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.7
- All Researches
9.5
We aimed to understand how curcumin, a compound found in turmeric, impacts knee pain in individuals suffering from osteoarthritis (OA). Using various databases, we gathered and analyzed data from multiple meta-analyses that included randomized controlled trials focused on curcumin's effects on OA symptoms up to September 2023.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
The results clearly demonstrated that curcumin supplementation substantially alleviates pain, as reflected in reduced scores on several pain measurement scales. These included the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) for pain, function, and stiffness.
Statistically significant improvements were observed across the board, highlighting that curcumin not only helps in reducing pain but also enhances joint function and decreases stiffness. This collectively suggests that curcumin can be an effective supplement for those managing knee OA, possibly minimizing the need for other medications.
Overall, our findings support the benefits of incorporating curcumin into treatment plans for osteoarthritis, offering a promising path for pain relief and improved mobility.
Read More
9
Topical curcumin gel effectiveness
We conducted a study to explore the effectiveness of a unique topical gel infused with curcumin, a key ingredient in turmeric, for treating knee osteoarthritis. This innovative gel utilizes a self-nano-emulsifying organogel system, which allows for better delivery of curcumin, a compound known for its challenging solubility and stability issues.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
Read More
9
Turmeric improves knee osteoarthritis
Our study focused on the impact of a specific combination of polyphenolic supplements, including turmeric, on knee pain for individuals with osteoarthritis. We conducted a randomized controlled trial with 60 participants, half of whom received the polyphenolic supplement featuring turmeric, rosemary extract, and resveratrol, while the other half received a placebo.
Over the course of 12 weeks, those taking the polyphenol supplement reported significantly reduced pain levels and improved physical functionality. The data was collected using validated questionnaires, demonstrating clearer benefits in this group compared to those on the placebo.
Notably, we observed that the polyphenol supplement also helped reduce systemic inflammation, which could be a key factor in easing knee pain. This suggests that turmeric, as part of the supplement, may play a beneficial role in managing not just pain, but also the overall quality of life for those suffering from knee osteoarthritis.
Over the course of 12 weeks, those taking the polyphenol supplement reported significantly reduced pain levels and improved physical functionality. The data was collected using validated questionnaires, demonstrating clearer benefits in this group compared to those on the placebo.
Notably, we observed that the polyphenol supplement also helped reduce systemic inflammation, which could be a key factor in easing knee pain. This suggests that turmeric, as part of the supplement, may play a beneficial role in managing not just pain, but also the overall quality of life for those suffering from knee osteoarthritis.
Read More
9
We studied the effects of curcumin, a compound in turmeric, alongside swimming to see how this combination could help alleviate knee pain caused by osteoarthritis (OA). In our research with rats, we set up five groups, with some getting the treatment and others serving as a control.
After injecting a substance that induces OA, we began a daily swimming regimen for certain groups and provided them with oral curcumin over four weeks. This combination proved to be the most effective in reducing pain and stiffness in the joints.
Not only did we notice improvement in the rats' discomfort, but there were also positive changes seen in their joint health when examined under a microscope. We observed a decrease in markers of inflammation, suggesting that the dual treatment could provide a more effective path for managing knee pain in osteoarthritis patients.
Overall, this research highlights the potential benefits of combining curcumin with physical activity like swimming for easing knee pain due to OA.
After injecting a substance that induces OA, we began a daily swimming regimen for certain groups and provided them with oral curcumin over four weeks. This combination proved to be the most effective in reducing pain and stiffness in the joints.
Not only did we notice improvement in the rats' discomfort, but there were also positive changes seen in their joint health when examined under a microscope. We observed a decrease in markers of inflammation, suggesting that the dual treatment could provide a more effective path for managing knee pain in osteoarthritis patients.
Overall, this research highlights the potential benefits of combining curcumin with physical activity like swimming for easing knee pain due to OA.
Read More
9
In our analysis, we investigated how a blend of several natural ingredients, including turmeric (CurQlife, curcumin), might alleviate knee pain in individuals suffering from osteoarthritis. Our study focused on the effects of this combination of nutraceuticals, known as Clagen™, which also includes native type 2 collagen, hyaluronic acid, and other supportive components.
We enrolled 100 patients with knee osteoarthritis and monitored their progress over two months. At the end of this period, we noted a significant reduction in pain levels, as evidenced by improved Visual Analog Scale (VAS) scores. Additionally, there were noticeable enhancements in the range of motion and overall quality of life for the participants.
While turmeric was part of the combination, we can't isolate its specific effects from those of the other ingredients. Nonetheless, this study suggests that combining these natural substances may offer a beneficial strategy for managing knee pain, potentially reducing the need for traditional pain medications like NSAIDs in the long run. However, further long-term studies are needed to confirm these findings.
We enrolled 100 patients with knee osteoarthritis and monitored their progress over two months. At the end of this period, we noted a significant reduction in pain levels, as evidenced by improved Visual Analog Scale (VAS) scores. Additionally, there were noticeable enhancements in the range of motion and overall quality of life for the participants.
While turmeric was part of the combination, we can't isolate its specific effects from those of the other ingredients. Nonetheless, this study suggests that combining these natural substances may offer a beneficial strategy for managing knee pain, potentially reducing the need for traditional pain medications like NSAIDs in the long run. However, further long-term studies are needed to confirm these findings.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Knee pain relief
2 people found this helpful
I have been taking this product for six months, and my osteoarthritis knee pain has almost disappeared. I keep purchasing it and no longer require anti-inflammatories. I wholeheartedly recommend it.
Read More
9
Avoided surgery
2 people found this helpful
My doctor told me I would need knee surgery, but I opted to try this turmeric first. Two years later, I’m thrilled to say I still haven’t needed surgery!
Read More
9
Reduced discomfort noted
After using the Turmeric Maximum Strength Joints & Mobility Supplement for about six weeks, I noticed a significant reduction in joint discomfort, notably in my knees. Initially, I experienced morning stiffness, but after consistent use, I have greater flexibility and less pain, particularly post-exercise.
Read More
9
Relieves joint pain
Although the pills are quite large, they are very effective. This is the only turmeric that genuinely alleviates my joint pain.
Read More
7.5
Less pain observed
I have to say this is one of my favourite products from Garden of Life. Although the tablets are large, they go down easily and do not irritate my stomach. The quality is exceptional and perfect for alleviating inflammation issues after intense exercise or outdoor work. I notice a significant difference with reliable turmeric sources like Garden of Life—less pain and more enjoyment in feeling my best.
Read More
Frequently Asked Questions
9
Reduced discomfort noted
After using the Turmeric Maximum Strength Joints & Mobility Supplement for about six weeks, I noticed a significant reduction in joint discomfort, notably in my knees. Initially, I experienced morning stiffness, but after consistent use, I have greater flexibility and less pain, particularly post-exercise.
6
Some relief observed
1 people found this helpful
I purchased this after seeing a YouTube recommendation regarding its quality. As I age, my knees and joints often ache, so I bought it to help alleviate the pain. After a week of use, it seems promising, and I intend to buy it again when I finish this bottle.
10
Knee pain relief
2 people found this helpful
I have been taking this product for six months, and my osteoarthritis knee pain has almost disappeared. I keep purchasing it and no longer require anti-inflammatories. I wholeheartedly recommend it.
9
Avoided surgery
2 people found this helpful
My doctor told me I would need knee surgery, but I opted to try this turmeric first. Two years later, I’m thrilled to say I still haven’t needed surgery!
7.5
Improved shoulder pain
3 people found this helpful
I had researched a reliable, high-dosage turmeric supplement for my frozen shoulder. After several months on this turmeric, my frozen shoulder has notably improved, with a significant increase in range of motion and reduced pain. Though it’s not cheap, I will continue taking it as it’s exceptionally strong, with each tablet containing 630mg of an organic turmeric blend, standardised to 95% curcuminoids.
0
No effectiveness noted
1 people found this helpful
I tried turmeric for joint pain but had no success. I learned the supplement I was using was ineffective due to low dosage and that it works best in combination with Capsaicin. After two bottles, I felt absolutely no impact on my arthritis pain. Though others may have their reasons for taking turmeric, for me, it was money wasted.
7.5
Reduces arthritis pain
3 people found this helpful
I have been taking this for over two years before bed. It really assists with my arthritis pain and other joint discomfort, allowing me to sleep soundly. This formula is also an antioxidant and contains excellent ingredients. I recommend it for reducing inflammation in your body and enhancing your well-being. The packaging is designed for a month's supply.
8
We delved into how turmeric might help alleviate knee pain associated with osteoarthritis (OA), a condition affecting a significant number of adults. The study we reviewed was a comprehensive systematic review and meta-analysis involving a total of ten randomized controlled trials with 786 participants.
The main focus was on evaluating the impact of turmeric on pain relief, specifically through the Visual Analog Scale (VAS) for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) total score. Turmeric showed promise by significantly improving pain scores compared to a placebo and demonstrated effects comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs).
With results highlighting an improvement in pain levels, both lower and higher dosages of turmeric were effective when compared to placebo. However, we also noted that the limitations and variability in the studies suggest that further research would be beneficial to determine the best dosages and methods for using turmeric as a treatment option for knee OA.
Overall, the findings suggest that turmeric could be a valuable alternative for those seeking relief from knee pain due to osteoarthritis, standing out against standard options like NSAIDs while having a potentially fewer side effects.
The main focus was on evaluating the impact of turmeric on pain relief, specifically through the Visual Analog Scale (VAS) for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) total score. Turmeric showed promise by significantly improving pain scores compared to a placebo and demonstrated effects comparable to those of nonsteroidal anti-inflammatory drugs (NSAIDs).
With results highlighting an improvement in pain levels, both lower and higher dosages of turmeric were effective when compared to placebo. However, we also noted that the limitations and variability in the studies suggest that further research would be beneficial to determine the best dosages and methods for using turmeric as a treatment option for knee OA.
Overall, the findings suggest that turmeric could be a valuable alternative for those seeking relief from knee pain due to osteoarthritis, standing out against standard options like NSAIDs while having a potentially fewer side effects.
9
Topical curcumin gel effectiveness
We conducted a study to explore the effectiveness of a unique topical gel infused with curcumin, a key ingredient in turmeric, for treating knee osteoarthritis. This innovative gel utilizes a self-nano-emulsifying organogel system, which allows for better delivery of curcumin, a compound known for its challenging solubility and stability issues.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
In our research, we utilized a double-blind clinical trial design to assess the outcomes of participants using the gel compared to those receiving a placebo over an eight-week period. The results were promising; those applying the gel experienced significant reductions in pain, stiffness, and physical function difficulties. Specifically, pain scores improved by 71.68% compared to only 7.03% in the placebo group.
Overall, this study highlights the potential of using curcumin in a new topical treatment that addresses knee pain effectively. While the gel specifically utilizes curcumin, it offers an alternative approach that leverages the benefits of turmeric without relying directly on the spice itself.
9
In a well-structured study involving 101 adults suffering from knee osteoarthritis, we explored the effects of curcumin, a compound derived from turmeric, on knee pain. Participants were randomly assigned to receive either 500 mg of a standardized curcumin extract, Curcugen, twice daily, or a placebo for eight weeks, allowing for a clear comparison of its effectiveness.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
Our findings revealed promising results. Curcumin significantly reduced knee pain scores and overall pain ratings compared to the placebo. We also noticed that participants taking curcumin showed greater improvements in various physical tests, like the timed up-and-go and six-minute walk tests, indicating enhanced mobility.
Interestingly, 37% of those on curcumin reduced their pain medications, which highlights the potential for curcumin to provide relief and improve quality of life for those with this condition. While the study didn’t explore longer treatment durations or different dosages, these initial results support curcumin's role as a feasible option for managing osteoarthritis pain in the knee.
8
We explored the effectiveness and safety of curcumin, a compound derived from turmeric, for treating knee osteoarthritis (KOA). Our research involved a comprehensive review of randomized controlled trials to assess how curcumin, whether alone or combined with other treatments, impacts knee pain.
The analysis indicated that curcumin has promising therapeutic potential for KOA, showing good clinical efficacy and a favorable safety profile. It's noteworthy that when curcumin is used in combination with other medications, it may not only enhance the treatment's effect but could also help in reducing side effects.
However, the combined use of treatments means we still await definitive conclusions about curcumin's isolated effects. There's a call for further clinical and basic research to uncover more about this promising approach.
The analysis indicated that curcumin has promising therapeutic potential for KOA, showing good clinical efficacy and a favorable safety profile. It's noteworthy that when curcumin is used in combination with other medications, it may not only enhance the treatment's effect but could also help in reducing side effects.
However, the combined use of treatments means we still await definitive conclusions about curcumin's isolated effects. There's a call for further clinical and basic research to uncover more about this promising approach.
8
We systematically reviewed several randomized controlled trials that focused on curcumin's effects on knee pain due to osteoarthritis. Our aim was to understand how low and high doses of curcumin might aid in pain relief and improve function compared to traditional non-steroidal anti-inflammatory drugs (NSAIDs). We gathered data from a variety of trusted medical databases, looking at studies published up until June 2021.
Our analysis included eleven studies with a total of 1,258 participants suffering from primary knee osteoarthritis. We discovered that curcuminoids, the active compounds in turmeric, provided meaningful pain relief, as shown by improvements in visual analogue scale (VAS) scores and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores when compared to other treatments.
Interestingly, we did not find significant differences in pain relief or adverse events (AEs) between high-dose (1,000 mg or more daily) and low-dose (less than 1,000 mg daily) curcumin treatments. However, curcuminoids were found to be more effective than NSAIDs in managing knee pain. While some studies reported higher adverse events in the NSAID group, only one study confirmed this finding was statistically significant.
Overall, our findings suggest that curcumin could be a beneficial supplement for those dealing with knee osteoarthritis, potentially serving as a supportive treatment alongside NSAIDs.
Our analysis included eleven studies with a total of 1,258 participants suffering from primary knee osteoarthritis. We discovered that curcuminoids, the active compounds in turmeric, provided meaningful pain relief, as shown by improvements in visual analogue scale (VAS) scores and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores when compared to other treatments.
Interestingly, we did not find significant differences in pain relief or adverse events (AEs) between high-dose (1,000 mg or more daily) and low-dose (less than 1,000 mg daily) curcumin treatments. However, curcuminoids were found to be more effective than NSAIDs in managing knee pain. While some studies reported higher adverse events in the NSAID group, only one study confirmed this finding was statistically significant.
Overall, our findings suggest that curcumin could be a beneficial supplement for those dealing with knee osteoarthritis, potentially serving as a supportive treatment alongside NSAIDs.
8
We assessed the effectiveness of turmeric, particularly its active ingredient curcumin, in alleviating knee pain associated with osteoarthritis (OA). This analysis included twelve studies, which involved a total of 1,438 participants, comparing those taking curcumin against placebo groups.
The findings revealed significant improvements in both pain and function for those receiving curcumin compared to the placebo group. However, there was no notable difference when curcumin was compared with other treatments like nonsteroidal anti-inflammatory drugs or paracetamol, which are commonly used for pain relief.
Additionally, we found that taking curcumin resulted in a favorable impact on inflammation markers, which can be an important aspect of managing OA symptoms. It's worth highlighting that while turmeric shows promising benefits for knee pain, further studies are needed to explore the effects of other supplements, like omega-3 and vitamin D.
The findings revealed significant improvements in both pain and function for those receiving curcumin compared to the placebo group. However, there was no notable difference when curcumin was compared with other treatments like nonsteroidal anti-inflammatory drugs or paracetamol, which are commonly used for pain relief.
Additionally, we found that taking curcumin resulted in a favorable impact on inflammation markers, which can be an important aspect of managing OA symptoms. It's worth highlighting that while turmeric shows promising benefits for knee pain, further studies are needed to explore the effects of other supplements, like omega-3 and vitamin D.
References
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. 10.3390/nu17020349
- Hidayat R, Parlindungan F, Nisa JI, Mahendra AI, Indika MI, et al. Efficacy of in relieving pain symptoms of knee osteoarthritis patients: a systematic review and meta-analysis of clinical trials. J Rheum Dis. 2025;32:17. 10.4078/jrd.2024.0062
- Baharizade M, Ghetmiri SI, Mohammady M, Mohammadi-Samani S, Yousefi G. Revolutionizing Knee Osteoarthritis Treatment: Innovative Self-Nano-Emulsifying Polyethylene Glycol Organogel of Curcumin for Effective Topical Delivery. AAPS PharmSciTech. 2024;25:80. 10.1208/s12249-024-02789-8
- Bideshki MV, Jourabchi-Ghadim N, Radkhah N, Behzadi M, Asemani S, et al. The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses. Phytother Res. 2024;38:2875. 10.1002/ptr.8153
- Zhao J, Liang G, Zhou G, Hong K, Yang W, et al. Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis. J Ethnopharmacol. 2024;321:117493. 10.1016/j.jep.2023.117493
- Valsamidou E, Amerikanou C, Tzavara C, Skarpas G, Mariolis-Sapsakos TD, et al. A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial. Heliyon. 2023;9:e20143. 10.1016/j.heliyon.2023.e20143
- Saber MM, Mahmoud MM, Amin HM, Essam RM. Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model. Biomed Pharmacother. 2023;166:115309. 10.1016/j.biopha.2023.115309
- Kamat YD, Das B, Thakkar K, Mahajan M. A Retrospective Observational Study Evaluating the Synergistic Effect of a Novel Combination of Alfapin + Native Type 2 Collagen + Mobilee (Hyaluronic Acid) + CurQlife (Curcumin) Nutraceuticals in the Symptomatic Improvement of Knee Osteoarthritis. Cureus. 2023;15:e36123. 10.7759/cureus.36123
- Sengupta S, Tripathi A. Evaluation of analgesic and prophylactic activity of curcumin against chikungunya-infected acute/chronic arthralgic mice. J Med Virol. 2023;95:e28661. 10.1002/jmv.28661
- Raj JP, Venkatachalam S, S Amaravati R. Safety and Efficacy of Moderately-High Dose Turmacin® (Turmerosaccharide >10% w/w) Supplementation on Joint Discomfort in Healthy Adults - A Pilot Proof-of-Concept Single Arm Study. J Diet Suppl. 2024;21:28. 10.1080/19390211.2023.2176577
- Feng J, Li Z, Tian L, Mu P, Hu Y, et al. Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther. 2022;22:276. 10.1186/s12906-022-03740-9
- Mathieu S, Soubrier M, Peirs C, Monfoulet LE, Boirie Y, et al. A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms. Nutrients. 2022;14. 10.3390/nu14081607
- Lopresti AL, Smith SJ, Jackson-Michel S, Fairchild T. An Investigation into the Effects of a Curcumin Extract (Curcugen) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study. Nutrients. 2021;14. 10.3390/nu14010041
- Hsiao AF, Lien YC, Tzeng IS, Liu CT, Chou SH, et al. The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis. Complement Ther Med. 2021;63:102775. 10.1016/j.ctim.2021.102775
- Shokri-Mashhadi N, Bagherniya M, Askari G, Sathyapalan T, Sahebkar A. A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis. Adv Exp Med Biol. 2021;1291:265. 10.1007/978-3-030-56153-6_16
- Dai W, Yan W, Leng X, Chen J, Hu X, et al. Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2021;35:5921. 10.1002/ptr.7204
